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Invitrogen™ Insulin Monoclonal Antibody (2D11-H5)
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Catalog No. 01671365 Shop All Thermo Scientific Products
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01-671-365 100 μg
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Catalog No. 01-671-365 Supplier Invitrogen™ Supplier No. MA135525
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Description

Mouse Monoclonal Antibody

Insulin is a protein consisting of an α-chain of 21 amino acids and a β-chain of 30 amino acids and produced in the β-cells of the pancreas. 2D11-H5 is a specific insulin antibody as tested by ELISA and on human pancreatic tissue.

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Insulin
Applications ELISA, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 2D11-H5
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene INS
Gene Accession No. P01308, P01311, P01315, P01317, P01325, P01326
Gene Alias AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin
Gene Symbols INS, Ins1, Ins2
Host Species Mouse
Immunogen Purified pig insulin, conjugated to KLH.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100009181, 16333, 16334, 280829, 3630, 397415
Target Species Human, Mouse, Rabbit, Bovine, Pig
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

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