Invitrogen™ Insulin Monoclonal Antibody (2D11-H5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135525

Catalog No. 01-671-365

Description

Insulin is a protein consisting of an α-chain of 21 amino acids and a β-chain of 30 amino acids and produced in the β-cells of the pancreas. 2D11-H5 is a specific insulin antibody as tested by ELISA and on human pancreatic tissue.

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

Specifications

• Antigen: Insulin
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P01308, P01311, P01315, P01317, P01325, P01326
• Gene Symbols: INS, Ins1, Ins2
• Immunogen: Purified pig insulin, conjugated to KLH.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rabbit, Bovine, Pig
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Clone: 2D11-H5
• Conjugate: Unconjugated
• Gene: INS
• Gene Alias: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 100009181, 16333, 16334, 280829, 3630, 397415
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov