Invitrogen™ Insulin Polyclonal Antibody

Guinea Pig Polyclonal Antibody

Supplier:  Invitrogen™ PA126938

Catalog No. PA126938

Description

This antibody stains beta(b) cells of the Langerhan's islets in human pancreas. IHC Note: prolonged fixation in buffered formalin can destroy the epitope.

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

Specifications

• Antigen: Insulin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: INS
• Gene Alias: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin
• Host Species: Guinea Pig
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
• Gene Accession No.: P01308, P01325, P01326
• Gene Symbols: INS, Ins1, Ins2
• Immunogen: Full length human protein.
• Regulatory Status: RUO
• Gene ID (Entrez): 16333, 16334, 3630
• Content And Storage: 4°C, do not freeze
• Form: Liquid