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Invitrogen™ Integrin beta 7 Monoclonal Antibody (473207)
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Catalog No. PIMA524192
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100 μg
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Catalog No. Quantity
PIMA524192 100 μg
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Catalog No. PIMA524192 Supplier Invitrogen™ Supplier No. MA524192
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Description

Mouse Monoclonal Antibody

In Western blots, no cross-reactivity with recombinant human Integrin beta 1, beta 2, beta 3, beta 4, beta 5, beta 6, beta 8, recombinant mouse Integrin beta 4, or beta 7 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin beta 7
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone 473207
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene ITGB7
Gene Accession No. P26010
Gene Alias Gut homing receptor beta subunit; integrin beta 7; integrin beta 7 subunit; integrin beta-7; Integrin beta-P; integrin subunit beta 7; integrin, beta 7; ITGB7; Ly69; M290 IEL antigen
Gene Symbols ITGB7
Host Species Mouse
Immunogen CHO-derived recombinant human Integrin beta 7 long isoform Glu20-His723.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3695
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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