Invitrogen™ Integrin beta 7 Recombinant Rat Monoclonal Antibody (FIB504)

Catalog No.	Quantity
PIMA548014	200 μg

Catalog No. PIMA548014

Supplier: Invitrogen™ MA548014

Description

Rat Recombinant Monoclonal Antibody

Specificity: FIB504 recognizes an epitope on intergin beta-7 subunit that overlaps completely with the epitope defined by Fib27 and Fib30, and also partially with the epitope defined by FIB21 and FIB22.

Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.

Specifications

• Antigen: Integrin beta 7
• Applications: Flow Cytometry, Inhibition Assays, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: FIB504
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% ProClin 300
• Gene: ITGB7
• Gene Accession No.: P26010, P26011
• Gene Alias: Gut homing receptor beta subunit; integrin beta 7; integrin beta 7 subunit; integrin beta-7; Integrin beta-P; integrin subunit beta 7; integrin, beta 7; ITGB7; Ly69; M290 IEL antigen
• Gene Symbols: ITGB7
• Host Species: Rat
• Immunogen: FIB504 was prepared by immunizing rats with TK1 cells.
• Purification Method: Protein A
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16421, 3695
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a κ