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Invitrogen™ Involucrin Monoclonal Antibody (SY5)
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Catalog No. PIMA511803
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500 μL
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PIMA511803 500 μL
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Catalog No. PIMA511803 Supplier Invitrogen™ Supplier No. MA511803
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Description

Mouse Monoclonal Antibody

MA5-11803 targets Involucrin in ELISA, IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Human, Non-human primate, Porcine, and Rat samples. The MA5-11803 immunogen is human keratinocytes' involucrin.

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Involucrin
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone SY5
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene IVL
Gene Accession No. P07476, P18174, P18175, P48998
Gene Alias 1110019C06Rik; involucrin; IVL
Gene Symbols IVL
Host Species Mouse
Immunogen Human keratinocytes' involucrin.
Purification Method Protein A/G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 101125010, 102152041, 3713, 407242, 60583
Target Species Canine, Human, Monkey, Pig, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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