Invitrogen™ Involucrin Monoclonal Antibody (SY5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA511803

Catalog No. PIMA511803

Description

MA5-11803 targets Involucrin in ELISA, IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Human, Non-human primate, Porcine, and Rat samples. The MA5-11803 immunogen is human keratinocytes' involucrin.

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.

Specifications

• Antigen: Involucrin
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P07476, P18174, P18175, P48998
• Gene Symbols: IVL
• Immunogen: Human keratinocytes' involucrin.
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Canine, Monkey, Pig
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: SY5
• Conjugate: Unconjugated
• Gene: IVL
• Gene Alias: 1110019C06Rik; involucrin; IVL
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 101125010, 102152041, 3713, 407242, 60583
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov