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Invitrogen™ IP3 Receptor 1 Polyclonal Antibody
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Catalog No. 01670201
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Catalog No. Quantity
01-670-201 100 μL
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Catalog No. 01-670-201 Supplier Invitrogen™ Supplier No. PA3901A
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Description

Rabbit Polyclonal Antibody

PA3-901A detects inositol 1,4,5-triphosphate receptor type-I (IP3R-I) from mouse, human and rat tissues. PA3-901A has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~240-260 kDa protein representing IP3R-I from rat and mouse brain extract. PA3-901A is a remanufactured lot of PA3-901 which has previously been used in Western blot, immunoprecipitation and immunohistochemistry procedures. The PA3-901A immunogen is a synthetic peptide corresponding to residues N(1829) K K K D D E V D R D A P S R K K A K E(1848) of human IP3 Receptor Type I. This sequence is 100% conserved in human, mouse, and rat IP3R-I protein. This peptide (Cat. # PEP-019) is available for use in neutralization and control experiments.

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IP3 Receptor 1
Applications Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum, PBS with 0.05% sodium azide
Gene Itpr1
Gene Accession No. P11881, P29994, Q14643
Gene Alias ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; inositol 1,4,5-trisphosphate-binding protein P400; InsP>3>R type I; Insp3r; InsP3R type I; insP3R1; IP3 receptor; IP3 receptor isoform 1; Ip3r; IP-3-R; IP3R 1; IP3R1; Itpr1; Itpr-1; opisthotonus; opt; P400; Pcd6; Pcp1; Pcp-1; PPP1R94; protein PCD-6; protein phosphatase 1, regulatory subunit 94; Purkinje cell protein 1; SCA15; SCA16; SCA29; SI-SIII-SIIA; Type 1 inositol 1,4,5-trisphosphate receptor; type 1 InsP3 receptor
Gene Symbols Itpr1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues N(1829) K K K D D E V D R D A P S R K K A K E(1848) of human IP3 Receptor Type I.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16438, 25262, 3708
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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