Invitrogen™ IP3 Receptor 2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA541009

Catalog No. PIPA541009

Description

Peptide sequence: FRDCLFKVCP MNRYSAQKQY WKAKQAKQGN HTEAALLKKL QHAAELEQKQ Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%.

Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to IP3R, IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. IP3R type I (IP3R-I) has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II is found predominantly in the brain. IP3R-III is known to be expressed in pancreatic islets, kidney, and the gastrointestinal tract.

Specifications

• Antigen: IP3 Receptor 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITPR2
• Gene Alias: AI649341; ANHD; CFAP48; cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor 5; inositol 1,4,5-triphosphate receptor, type 2; inositol 1,4,5-trisphosphate receptor type 2; inositol 1,4,5-trisphosphate receptor, type 2; inositol 1,4,5-trisphosphate type V receptor; inositol triphosphate receptor type 2; inositol trisphosphate receptor type 2; insP3R2; InsP3R-2; InsP3R-5; IP3 receptor; IP3 receptor isoform 2; IP3 receptor/Ca2+ channel type 2; IP3R; IP3R 2; IP3R2; Itpr2; Itpr5; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2; si:dkey-196d8.1; Type 2 inositol 1,4,5-trisphosphate receptor; type 2 InsP3 receptor
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3709
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q14571
• Gene Symbols: ITPR2
• Immunogen: Synthetic peptide directed towards the N-terminal of human ITPR2 (aa 53-102).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov