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Invitrogen™ IP3 Receptor 2 Polyclonal Antibody
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Catalog No. PIPA5141118
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100 μL
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PIPA5141118 100 μL
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Catalog No. PIPA5141118 Supplier Invitrogen™ Supplier No. PA5141118
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Description

Rabbit Polyclonal Antibody

IP3 Receptor 2 Polyclonal Antibody for DB, Flow, ICC/IF, IHC (P)

Inositol 1,4,5-trisphosphate (IP3) is a second messenger for many growth factors, hormones, and neuro-transmitters. Upon binding to IP3R, IP3 triggers the release of intracellular, luminal calcium to the cytosol. Functional IP3R is a homo- or heterotetramer of ~240 kDa glycoprotein subunits. IP3R protein is structurally and functionally related to one other important intracellular calcium-release channel, the ryanodine receptor. The similarity between the two receptors continues at the physiological level owing to a physical association each receptor can have with the immunophilin protein, FKBP12. Phosphorylation of the IP3R by PKC causes an increase in IP3-mediated calcium release. Concomitantly, the phosphatase activity of calcineurin is stimulated upon its association with the FKBP12-IP3R complex. Calcium release is reduced when the PKC target site on the IP3R is dephosphorylated by calcineurin resulting in calcium oscillations. Mammalian IP3R subunits are the product of three distinct genes that are widely expressed and differentially regulated. IP3R type I (IP3R-I) has been detected in heart, liver, kidney, ovary, and Purkinje neurons of the cerebellum. IP3R-II is found predominantly in the brain. IP3R-III is known to be expressed in pancreatic islets, kidney, and the gastrointestinal tract.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IP3 Receptor 2
Applications Dot Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gene ITPR2
Gene Accession No. P29995, Q14571, Q9Z329
Gene Alias AI649341; ANHD; CFAP48; cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor 5; inositol 1,4,5-triphosphate receptor, type 2; inositol 1,4,5-trisphosphate receptor type 2; inositol 1,4,5-trisphosphate receptor, type 2; inositol 1,4,5-trisphosphate type V receptor; inositol triphosphate receptor type 2; inositol trisphosphate receptor type 2; insP3R2; InsP3R-2; InsP3R-5; IP3 receptor; IP3 receptor isoform 2; IP3 receptor/Ca2+ channel type 2; IP3R; IP3R 2; IP3R2; Itpr2; Itpr5; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2; si:dkey-196d8.1; Type 2 inositol 1,4,5-trisphosphate receptor; type 2 InsP3 receptor
Gene Symbols ITPR2
Host Species Rabbit
Immunogen Recombinant protein within human ITPR2 aa 1100-1450.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16439, 3709, 81678
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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