Invitrogen™ IPO5 Monoclonal Antibody (N9C1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA110886

Catalog No. 01-671-891

Description

MA1-10886 detects PSE1/Ku Protein from human samples. MA1-10886 has been successfully used in Western blot applications. The MA1-10886 immunogen is Proximal Sequence Element (PSE1) of the human U1 small nuclear RNA extracted from human placenta.

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

Specifications

• Antigen: IPO5
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: O00410
• Gene Symbols: IPO5
• Immunogen: Proximal sequence element (PSE1) of the human U1 small nuclear RNA extracted from human placenta.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: N9C1
• Conjugate: Unconjugated
• Gene: IPO5
• Gene Alias: 1110011C18Rik; 5730478E03Rik; AA409333; C76941; IMB3; imp5; importin 5; importin beta-3 subunit; importin subunit beta-3; Importin-5; IPO 5; IPO5; karyopherin (importin) beta 3; Karyopherin beta 3; karyopherin beta-3; Kpnb3; MGC2068; Pse1; RAN binding protein 5; Ran_GTP binding protein 5; ran-binding protein 5; RanBP 5; Ranbp5
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 3843
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid