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Invitrogen™ IRAK4 Polyclonal Antibody
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Catalog No. PIPA520018
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100 μg
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Catalog No. Quantity
PIPA520018 100 μg
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Catalog No. PIPA520018 Supplier Invitrogen™ Supplier No. PA520018
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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~50kDa. A suggested positive control is K562 cell lysate. PA5-20018 can be used with blocking peptide PEP-0137.

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRAK4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene IRAK4
Gene Accession No. Q9NWZ3
Gene Alias 8430405M07Rik; 9330209D03Rik; interleukin 1 receptor associated kinase 4; interleukin-1; interleukin-1 receptor-associated kinase 4; IPD1; Irak4; IRAK-4; NY-REN-64; REN64; renal carcinoma antigen NY-REN-64
Gene Symbols IRAK4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids at the carboxy terminus of human IRAK-4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51135
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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