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Invitrogen™ IRAK4 Polyclonal Antibody
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Catalog No. 01676652
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100 μg
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Catalog No. Quantity
01-676-652 100 μg
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Catalog No. 01-676-652 Supplier Invitrogen™ Supplier No. PA141054
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Description

Rabbit Polyclonal Antibody

Suggested positive control: antigen standard for IRAK4 (transient overexpression lysate), NIH-3T3 whole cell lysate.

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRAK4
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene IRAK4
Gene Accession No. Q8R4K2, Q9NWZ3
Gene Alias 8430405M07Rik; 9330209D03Rik; interleukin 1 receptor associated kinase 4; interleukin-1; interleukin-1 receptor-associated kinase 4; IPD1; Irak4; IRAK-4; NY-REN-64; REN64; renal carcinoma antigen NY-REN-64
Gene Symbols IRAK4
Host Species Rabbit
Immunogen Mixture of synthetic peptides containing amino acids 38-54 and 120-136 of mouse IRAK-4.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 266632, 300177, 51135
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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