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Eurofins Discoverx IRE1, active, 10 µg. (14-930)
Supplier: Eurofins Discoverx 14930
N-terminal 6xHis-tagged recombinant, human IRE1 amino acids 465-end. Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. For detailed product information, visit www.discoverx.com/proteins.
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