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IREM-2 (CD300e) Mouse anti-Human, Alexa Fluor 647, Clone: UP-H1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 566315

Catalog No. BDB566315


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Description

Description

The UP-H1 monoclonal antibody recognizes Immune receptor expressed by myeloid cells 2 (IREM-2) which is also known as CD300 antigen like family member E (CD300e), CMRF35-like molecule 2 (CLM2), or Polymeric immunoglobulin receptor 2 (PIgR2). IREM-2 is a 34 kDa type I transmembrane glycoprotein which belongs to the CMFRF35 subfamily of the immunoglobulin (Ig) superfamily. IREM-2 is expressed on monocytes, macrophages and myeloid dendritic cells (mDCs), but not on lymphoid dendritic cells or granulocytes. IREM-2 associates with DAP-12, an ITAM-containing adapter molecule, which provides activating signals. Crosslinking of IREM-2 leads to intracellular calcium mobilization, release of proinflammatory cytokines such as TNF, and increased expression of activation markers on monocytes and mDCs. IREM-2 activation of mDCs can reportedly enhance the alloreactive response of naive T cells.

Alexa Fluor™ 647 conjugates are highly photostable and remain fluorescent over a broad pH range. The excitation and emission maxima are nearly identical to those of APC. However, APC tends to be brighter while Alexa Fluor™ 647 is more optimal for intracellular applications. This fluorochrome exhibits uncommon photostability, making it an ideal choice for use in fluorescence microscopy. Due to nearly identical excitation and emission properties but different spillover characteristics, APC and Alexa Fluor™ 647 cannot be used simultaneously.
Specifications

Specifications

IREM-2 (CD300e)
Alexa Fluor 647
Affinity Purified
Murine
Mouse IgG2a, κ
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
UP-H1
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IREM2, CD300E, CD300LE, CLM2, CLM-2, CMRF35-A5, PIgR-2, LMIR6
Human IREM-2 Transfected Cell Line
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to Alexa Fluor™ 647 under optimum conditions, and unreacted Alexa Fluor™ 647 was removed.
RUO
Primary
Human
Documents
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