Invitrogen™ IRF8 Monoclonal Antibody (ZI003)

Catalog No.	Quantity
39-880-0	100 μg

Catalog No. 39-880-0 Supplier Invitrogen™ Supplier No. 398800

Description

Mouse Monoclonal Antibody

IRF8 Monoclonal Antibody for Western Blot, ELISA

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

Specifications

• Antigen: IRF8
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: ZI003
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene: Irf8
• Gene Accession No.: P23611, Q02556
• Gene Alias: AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
• Gene Symbols: Irf8
• Host Species: Mouse
• Immunogen: Synthetic peptide derived from the C-terminal region of the human ICSBP protein.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 15900, 3394
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ