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Invitrogen™ IRGC Polyclonal Antibody
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Catalog No. PIPA5103434
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PIPA5103434 100 μL
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Catalog No. PIPA5103434 Supplier Invitrogen™ Supplier No. PA5103434
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total IRGC.

Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRGC
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Irgc
Gene Accession No. Q6NXR0
Gene Alias CINEMA; cinema 1; F630044M05Rik; Gm1102; Gm474; IFGGE; Iigp5; immunity related GTPase cinema; immunity-related GTPase cinema 1; immunity-related GTPase family, cinema; immunity-related GTPase family, cinema 1; interferon inducible GTPase 5; interferon inducible GTPase family member 5; interferon-gamma-inducible GTPase IFGGE protein; interferon-inducible GTPase 5; Irgc; IRGC1; R30953_1; RGD1311107
Gene Symbols Irgc
Host Species Rabbit
Immunogen A synthesized peptide derived from human IRGC(Accession Q6NXR0), corresponding to amino acid residues A279-V329.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56269
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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