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  5. 183810

IRL-2500, Tocris Bioscience™
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Catalog No. 183810
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent ETB antagonist

Potent endothelin receptor antagonist; shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.

Chemical Identifiers

CAS 169545-27-1
Molecular Formula C36H35N3O4
Molecular Weight (g/mol) 573.693
InChI Key UZDORQWMYRRLQV-JHOUSYSJSA-N
Synonym chembl72410, 2s-2-2r-2-3,5-dimethylbenzoyl-methylamino-3-4-phenylphenyl propanoyl amino-3-1h-indol-3-yl propanoic acid, tocris-1838, d01ede, n-3-1,1'-biphenyl-4-yl-n-3,5-dimethylbenzoyl-n-methyl-d-alanyl-l-tryptophan, 2s-2-2r-3-1,1'-biphenyl-4-yl-2-1-3,5-dimethylphenyl-n-methylformamido propanamido-3-1h-indol-3-yl propanoic acid, s-2-r-3-biphenyl-4-yl-2-3,5-dimethyl-benzoyl-methyl-amino-propionylamino-3-1h-indol-3-yl-propionic acid
PubChem CID 5311192
IUPAC Name (2S)-2-[[(2R)-2-[(3,5-dimethylbenzoyl)-methylamino]-3-(4-phenylphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
SMILES CC1=CC(=CC(=C1)C(=O)N(C)C(CC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)O)C

Specifications

Quantity 10 mg
Formula Weight 573.69
Percent Purity >99%
Chemical Name or Material IRL-2500

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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