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AdipoGen Isorhamnetin (5 mg)
Supplier: AdipoGen CDXI0174M005
Chemical. CAS: 480-19-3. Formula: C16H12O7. MW: 316.26. Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin. It shows diverse biological activities, including antioxidant, cardioprotective, anti-inflammatory, neuroprotective, antiobesity, antiviral, antituberculosis and anticancer properties. Isorhamnetin exerts anticancer activity, through induction of apoptosis and inhibition of cell proliferation and invasion. It suppresses colon cancer cell growth through the PI3K-Akt-mTOR pathway. It inhibits the NF-kappaB signaling pathway. Isorhamnetin selectively inhibited NLRP3 and AIM2 inflammasome activation and down-regulated expression of pro-inflammatory cytokines. It has powerful antioxidant action through its ability to scavenge free radicals and inhibits xanthine oxidase. Isorhamnetin is a PPARgamma antagonist and inhibits adipogenesis, with beneficial effect on the prevention and treatment of obesity.
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