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Tocris Bioscience™ ITD 1

Catalog No. p-5545836
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Catalog No. Quantity
50-685-0R 50 mg
50-681-0 10 mg
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Catalog No. 50-685-0R Supplier Tocris Bioscience™ Supplier No. 5068/50
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Description

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

ITD 1 is a selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

Specifications

Purity >98%
Content And Storage -20°C
Quantity 50 mg
Product Type ITD 1
Molecular Weight (g/mol) 415.52
Inhibitors ITD 1

For Research Use Only

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