ITGB3BP Monoclonal Antibody (OTI4H1), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA803458

Catalog No. 50-167-9758

Description

ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Specifications

• Antigen: ITGB3BP
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q13352
• Gene Symbols: ITGB3BP
• Immunogen: Full length human recombit protein of human ITGB3BP produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI4H1
• Conjugate: Unconjugated
• Gene: ITGB3BP
• Gene Alias: CENP-R, CENPR, HSU37139, NRIF3, TAP20
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23421
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid