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Invitrogen™ ITM2B Monoclonal Antibody (OTI1C11)
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Catalog No. PIMA525513
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100 μL
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PIMA525513 100 μL
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Catalog No. PIMA525513 Supplier Invitrogen™ Supplier No. MA525513
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Description

Mouse Monoclonal Antibody

ITM2B Monoclonal Antibody for Western Blot, IHC (P), Flow

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITM2B
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1C11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ITM2B
Gene Accession No. Q9Y287
Gene Alias ABRI; ABri/ADan amyloid peptide; ABri23; AI256040; Bri; BRI2; BRI2 ICD; BRI2 intracellular domain; BRI2, membrane form; Bri2-23; Bri23 peptide; BRI2C, soluble form; Bricd2b; BRICHOS domain containing 2B; C-terminal peptide; D14Sel6; E25B; E25BMM; E3-16; FBD; imBRI2; Immature BRI2; integral membrane protein 2B; Integral membrane protein 2B (E25B protein); ITM2B; Mature BRI2; mBRI2; OTTHUMP00000018394; P23 peptide; Protein E25B; RDGCA; RP11-196P14.1; Transmembrane protein BRI
Gene Symbols ITM2B
Host Species Mouse
Immunogen Full length human recombinant protein of ITM2B produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9445
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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