Tocris Bioscience™ Itraconazole

Catalog No.	Quantity
59-815-0	50 mg

Catalog No. 59-815-0 Supplier Tocris Bioscience™ Supplier No. 5981/50

Description

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

Itraconazole is a SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.

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Specifications

• Chemical Name or Material: 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
• CAS: 84625-61-6
• Quantity: 50 mg
• Target: Smoothened Receptor Antagonists
• Molecular Formula: C₃₅H₃₈Cl₂N₈O₄
• Formula Weight: 705.63
• Purity: >99%