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Tocris Bioscience™ Itraconazole
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)
Supplier: Tocris Bioscience™ 5981/50
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Description
Itraconazole is a SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.Specifications
4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one | |
50 mg | |
C35H38Cl2N8O4 | |
>99% |
84625-61-6 | |
Smoothened Receptor Antagonists | |
705.63 |
Safety and Handling
Recommended Storage : Store at -20°C
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