Itraconazole, 98%

Description

CAS: 84625-61-6 | C35H38Cl2N8O4 | 705.64 g/mol

Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It?s different formulations are used to study Candida strains in murine invasive infections. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats..

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It′s different formulations are used to study Candida strains in murine invasive infections. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats..

Solubility
Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Specifications

Chemical Identifiers

• CAS: 84625-61-6
• Molecular Formula: C35H38Cl2N8O4
• Molecular Weight (g/mol): 705.64
• MDL Number: MFCD00870168,MFCD00941396
• InChI Key: VHVPQPYKVGDNFY-ZPGVKDDISA-N
• Synonym: Oriconazole; R51211
• PubChem CID: 45039617
• IUPAC Name: 1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
• SMILES: CCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1

• Type: Itraconazole
• Physical Form: Powder
• Melting Point: 166°C
• Color: White
• Quantity: 1 g
• Flash Point: >110°C (230°F)
• Merck Index: 14,5245
• Solubility Information: Insoluble in water; Solube in chloroform at 50mg/ml; Slightly soluble in ethanol or methanol
• Formula Weight: 705.63
• Percent Purity: 98%
• Chemical Name or Material: Itraconazole

Safety and Handling

Hazard Category	H302-H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
RTECSNumber	XZ5481000
TSCA	No
storageNote1	2° to 8°C
Recommended Storage	Keep cold

SDS

RUO – Research Use Only