Thermo Scientific Chemicals Itraconazole, 99%

Description

Itraconazole, or voriconazole, CAS # 84625-61-6, is an N-arylpiperazine that has antifungal properties. | CAS: 84625-61-6 | C35H38Cl2N8O4 | 705.64 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Itraconazole is an aromatic ether that works as a strong inhibitor of P-glycoproteins and CYP3A4

• Itraconazole also acts as a hedgehog signaling inhibitor and P450 inhibitor

Applications

• Itraconazole can be exhibits antifungal activity against organisms including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis

• Itraconazole may be used to experimentally target the delivery of other molecules, such as plasmids, to cells

Specifications

Chemical Identifiers

• CAS: 84625-61-6
• Molecular Formula: C35H38Cl2N8O4
• Molecular Weight (g/mol): 705.64
• MDL Number: MFCD00870168,MFCD00941396
• InChI Key: VHVPQPYKVGDNFY-ZPGVKDDISA-N
• Synonym: itraconazole-d5, itraconazole, oriconazole-d5, triasporin-d5, sporamelt-d5, itrizole-d5, sporanox-d5, +/--4-4-4-4-2r,4s-2,4-dichlorophenyl-2-1h-1,2,4-triazol-1-ylmethyl-1,3-dioxolan-4-yl methoxy phenyl-1-piperazinyl phenyl-2,4-dihydro-2-1-methylpropyl-d5-3h-1,2,4-triazol-3-one, 2h5-4-4-4-4-2-1h-1,2,4-triazol-1-yl methyl-2-2,4-dichlorophenyl-1,3-dioxolan-4-yl methoxy phenyl piperazin-1-yl phenyl-1-sec-butyl-1h-1,2,4-triazol-5 4h-one, 2-3,3,4,4,4-2 h? butan-2-yl-4-4-4-4-2r,4s-2-2,4-dichlorophenyl-2-1,2,4-triazol-1-ylmethyl-1,3-dioxolan-4-yl methoxy phenyl piperazin-1-yl phenyl-1,2,4-triazol-3-one
• PubChem CID: 45039617
• IUPAC Name: 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3,3,4,4,4-pentadeuteriobutan-2-yl)-1,2,4-triazol-3-one
• SMILES: CCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1

• Melting Point: 168.0°C to 170.0°C
• Loss on Drying: 0.5% max.
• Infrared Spectrum: Authentic
• Assay Percent Range: 98.5% min. (HPLC)
• Quantity: 5 g
• Merck Index: 15,5292
• Solubility Information: Solubility in water: <1mg/mL. Other solubilities: solubility in ethanol: <1mg/mL, solubility in dmso: 4mg/mL
• Formula Weight: 705.64
• Percent Purity: 99%
• Chemical Name or Material: Itraconazole

Safety and Handling

Hazard Category	GHS Signal Word: Warning
Hazard Statement	GHS H Statement Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	GHS P Statement Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: rinse mouth. Do NOT induce vomiting.

SDS

RUO – Research Use Only