Ivermectin, Tocris Bioscience™

Description

Allosteric modulator of α7 nicotinic receptors

Positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic and antiviral. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). Inhibits replication of SARS-CoV-2 in vitro (IC50 ∽ 2μM).

This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b.

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Specifications

Chemical Identifiers

• CAS: 70288-86-7
• Molecular Formula: C48H74O14
• Molecular Weight (g/mol): 875.106
• InChI Key: AZSNMRSAGSSBNP-RDKIRRGNSA-N
• Synonym: ivermectin
• PubChem CID: 122172888
• SMILES: CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C

• Quantity: 100 mg
• Formula Weight: 875.1
• Percent Purity: >96%
• Chemical Name or Material: Ivermectin

Safety and Handling

Recommended Storage

Desiccate at +4°C