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Invitrogen™ J Chain Monoclonal Antibody (Mc19-9)

Catalog No. MA180527
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Quantity:
200 μg
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Catalog No. Quantity
MA180527 200 μg
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Catalog No. MA180527 Supplier Invitrogen™ Supplier No. MA180527

Description

Mouse Monoclonal Antibody

This antibody does not detect J chain in intact IgM in ELISA Assays due to steric hindrance. In Western Blotting techniques MA1-80527 detects J chain in IgM only under reducing conditions. Mouse anti Human J chain antibody, clone Mc19-9 reacts with human J chain as tested by ELISA using purified human Ig fragments as the solid phase target antigen.

J chain is a small glycopeptide and is structurally unrelated to heavy or light chains, but is synthesized by all plasma cells that secrete polymeric immunoglobulins. J chain is linked to IgA and IgM by disulfide bonds, however, it has been detected in IgG- and IgD-containing cells. J chains are present in a large proportion of the immunoglobulin-positive cells in the germinal centers of the tonsil and lymph node. B cells secrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM.
TRUSTED_SUSTAINABILITY

Specifications

Antigen J Chain
Applications ELISA, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone Mc19-9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with <0.1% sodium azide
Gene JCHAIN
Gene Accession No. P01591
Gene Alias 9530090F24Rik; AI323815; IGCJ; Igj; IgJ chain; immunoglobulin J chain; immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides; immunoglobulin joining chain; immunoglobulin joining gene (not J region); J chain; Jch; JCHAIN; Joining chain of multimeric IgA and IgM
Gene Symbols JCHAIN
Host Species Mouse
Immunogen Human J Chain.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3512
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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