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  6. Invitrogen™ Jagged 2 Monoclonal Antibody (HMJ2-1), eFluor™ 660, eBioscience™, Invitrogen™ 

Invitrogen™ Jagged 2 Monoclonal Antibody (HMJ2-1), eFluor™ 660, eBioscience™, Invitrogen™
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Catalog No. p-7218871
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100 μg
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Catalog No. Quantity
50-339-282 100 μg
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Catalog No. 50-339-282 Supplier Invitrogen™ Supplier No. 50339282
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Description

Armenian Hamster Monoclonal Antibody

This HMJ2-1 MAb reacts with mouse Jagged-2, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Jagged-2 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Jagged-2 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen. Note: Staining of endogenous splenic dendritic (CD8+CD11c+) cells could only be consistently confirmed in cells isolated from C57BL/6, but not Balb/c, mice. Other strains have not been tested. The antiobdy has been reported to crossreact to rat and have blocking function.

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. JAG2 is one of several ligands that activate Notch and related receptors.
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Specifications

Antigen Jagged 2
Applications Flow Cytometry
Classification Monoclonal
Clone HMJ2-1
Concentration 0.2 mg/mL
Conjugate eFluor 660
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Jag2
Gene Accession No. P97607, Q9QYE5
Gene Alias D12Ggc2e; HJ2; JAG2; jagged 2; Jagged2; mJagged2-1; protein jagged-2; SER2; Serh; sm; syndactylism
Gene Symbols Jag2
Host Species Armenian Hamster
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16450, 29147
Target Species Mouse, Rat
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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