JAK2 Mouse anti-Human, Mouse, Clone: OTI1H9, liquid, TrueMAB™

Catalog No.	Quantity
50-168-1258	100 μL

Catalog No. 50-168-1258 Supplier OriGene Supplier No. TA806795

Description

Mouse Monoclonal Antibody

Janus Activating Kinase 2 (JAK2) is a non-rececptor tyrosine kinase involved in various processes such as cell growth, development, differentiation, and histone modifications. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting this gene can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

Specifications

• Antigen: JAK2
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI1H9
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: JAK2
• Gene Accession No.: O60674, Q62120
• Gene Alias: JTK10, THCYT3
• Gene Symbols: JAK2
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 297-596 of human JAK2 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16452, 3717
• Target Species: Human, Mouse
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1