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  5. Tocris Bioscience™ JIB 04

Tocris Bioscience™ JIB 04
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Catalog No. 497210R
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Pan Jumonji inhibitor; active in vivo

JIB 04 is a pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.

Specifications

Quantity 10 mg
Product Type JIB 04
Purity >99%
Molecular Weight (g/mol) 308.76
Inhibitors JIB 04

For Research Use Only

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