JMJD1A/JHDM2A Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-156-0646	20 μL

Catalog No. 50-156-0646 Supplier Bethyl Laboratories, Inc Supplier No. A301539AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

JMJD1A is a histone demethylase that specifically demethylates ′Lys-9′ of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 ′Lys-9′ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ′Lys-9′. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ′Lys-9′ demethylation and transcriptional activation. It′s also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Specifications

• Antigen: JMJD1A/JHDM2A
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: KDM3A
• Gene Accession No.: Q9Y4C1
• Gene Alias: TSGA; JMJD1; JHDM2A; JHMD2A; JMJD1A; KIAA0742; DKFZp686A24246; DKFZp686P07111; KDM3A
• Gene Symbols: KDM3A
• Host Species: Rabbit
• Immunogen: Between 1271 and 1321
• Purification Method: Antigen affinity chromatography
• Quantity: 20 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55818
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG