JMJD1A/JHDM2A Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A301538AT

Catalog No. 50-156-0643

Description

The recommended shelf life for this product is 1 year from date of receipt.

JMJD1A is a histone demethylase that specifically demethylates ′Lys-9′ of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 ′Lys-9′ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ′Lys-9′. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ′Lys-9′ demethylation and transcriptional activation. It′s also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Specifications

• Antigen: JMJD1A/JHDM2A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDM3A
• Gene Alias: TSGA; JMJD1; JHDM2A; JHMD2A; JMJD1A; KIAA0742; DKFZp686A24246; DKFZp686P07111; KDM3A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55818
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunoprecipitation
• Concentration: 1 mg/ml
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene Accession No.: Q9Y4C1
• Gene Symbols: KDM3A
• Immunogen: Between 1025 and 1075
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG