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JMJD2B Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501560498
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20 μL; Unconjugated
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Catalog No.
50-156-0498 20 μL; Unconjugated
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Catalog No. 50-156-0498 Supplier Bethyl Laboratories, Inc Supplier No. A301478AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Like other members of the JMJD1 and JMJD2 families, JMJD2B is a histone demethylase, but is reported to be a very poor enzyme. Similar to JMJD1A, JMJD2B is a transcriptional target of the hypoxia-inducible factor (HIF), and hypoxic cells express elevated levels of the JMJD2B mRNA and protein. Both JMJD1A and JMJD2B retain their histone demethylase activity in hypoxic conditions, suggesting that this activity of JMJD2B might play a role in the hypoxic gene expression program.

Specifications

Antigen JMJD2B
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene KDM4B
Gene Accession No. O94953, Q91VY5
Gene Alias JMJD2B; jmjC domain-containing histone demethylation protein 3B; jumonji domain containing 2B; jumonji domain-containing protein 2B; lysine-specific demethylase 4B
Gene Symbols Kdm4b
Host Species Rabbit
Immunogen Between 1056 and 1096
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 193796, 23030
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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