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JMJD2B Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A301477AT

Encompass_Preferred

Catalog No. 50-156-0495


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Like other members of the JMJD1 and JMJD2 families, JMJD2B is a histone demethylase, but is reported to be a very poor enzyme. Similar to JMJD1A, JMJD2B is a transcriptional target of the hypoxia-inducible factor (HIF), and hypoxic cells express elevated levels of the JMJD2B mRNA and protein. Both JMJD1A and JMJD2B retain their histone demethylase activity in hypoxic conditions, suggesting that this activity of JMJD2B might play a role in the hypoxic gene expression program.
Specifications

Specifications

JMJD2B
Polyclonal
Unconjugated
KDM4B
JMJD2B; jmjC domain-containing histone demethylation protein 3B; jumonji domain containing 2B; jumonji domain-containing protein 2B; lysine-specific demethylase 4B
Rabbit
Antigen affinity chromatography
RUO
23030
4° C
Liquid
Immunoprecipitation
1 mg/ml
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
O94953
KDM4B
Between 625 and 675
10 μL
Primary
Human
Antibody
IgG
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