Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
JMJD3 / KDM6B Mouse anti-Human, Mouse, Clone: 67-A2, Active Motif™ 
Mouse Monoclonal Antibody
$135.30 - $534.00
Specifications
| Monoclonal or Polyclonal | Monoclonal |
|---|---|
| Primary or Secondary | Primary |
| Antigen | JMJD3 / KDM6B |
| Conjugate | Unconjugated |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|
50-199-3364
|
Active Motif
61388 |
10 μg |
Each for $135.30
|
|
50-199-3363
|
Active Motif
61387 |
100 μg |
Each for $534.00
|
|
Description
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.Specifications
| Monoclonal | |
| Primary | |
| JMJD3 / KDM6B | |
| Unconjugated |
Provide Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title