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JMJD3 / KDM6B Mouse anti-Human, Mouse, Clone: 67-A2, Active Motif™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$135.30 - $534.00

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen JMJD3 / KDM6B
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3364 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
61388
10 μg
Each for $135.30
Add to cart
 
50-199-3363 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
61387
100 μg
Each for $534.00
Add to cart
 
Description

Description

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Specifications

Specifications

Monoclonal
Primary
JMJD3 / KDM6B
Unconjugated
SDS
Product Certifications
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