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JMJD3 / KDM6B Monoclonal Antibody (67-A2), Active Motif™
SDP

Mouse Monoclonal Antibody

$156.65 - $620.58

Specifications

Antigen JMJD3 / KDM6B
Clone 67-A2
Concentration 1 mg/mL
Applications Western Blot
Classification Monoclonal
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3364
SDP
Encompass
View Documents
Active Motif
61388
10 μg
Each for $156.65
Only null left
Add to Cart
 
50-199-3363
SDP
Encompass
View Documents
Active Motif
61387
100 μg
Each for $620.58
Only null left
Add to Cart
 
Description

Description

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Specifications

Specifications

JMJD3 / KDM6B
1 mg/mL
Monoclonal
Liquid
RUO
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
1700064E03Rik; BC038313; JmjC domain-containing protein 3; Jmjd3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jumonji domain-containing 3; Jumonji domain-containing protein 3; KDM1 lysine (K)-specific demethylase 6B; Kdm6b; Kiaa0346; lysine (K)-specific demethylase 6B; Lysine demethylase 6B; Lysine-specific demethylase 6B; mKIAA0346
KDM6B
IgG1
Protein A
Antibody
67-A2
Western Blot
Unconjugated
Mouse
Human, Mouse
O15054, Q5NCY0
216850, 23135
This antibody was raised against a recombinant protein corresponding to amino acids 1028-1684 of human JMJD3 / kDM6B.
Primary
-20°C, Avoid Freeze/Thaw Cycles
KDM6B
Videos
SDS
Documents

Documents

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