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  5. Tocris Bioscience™ JNJ 55511118

Tocris Bioscience™ JNJ 55511118
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Catalog No. 62785
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Catalog No. Quantity
62-785 5 mg
62-782-5 25 mg
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Catalog No. 62-785 Supplier Tocris Bioscience™ Supplier No. 6278/5
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Description

Selective, high affinity negative modulator of AMPA receptors containing TARP-γ8

JNJ 55511118 is a high affinity and selective negative modulator of AMPA receptors containing TARP-γ8 (Ki = 26 nM). Exhibits <50% binding against a panel of 52 receptors, ion channels and transporters (except 5HT2B and melatonin receptors 78% and 57%, respectively). Also displays minimal activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. It reduces alcohol self-administration in a mouse models of chronic drinking. Orally bioavailable and brain penetrant. Anticonvulsant.

Specifications

Chemical Name or Material 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one
CAS 2036081-86-2
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C14H8ClF3N2O2
Formula Weight Observed MW: 328.67
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