Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ JQEZ5

Tocris Bioscience™ JQEZ5
GREENER_CHOICE

Catalog No. 615310
missing translation for 'changeView'
Click to view available options
Quantity:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
61-531-0 10 mg
61-535-0 50 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 missing translation for 'options'
missing translation for 'nonReturnableMessage' missing translation for 'returnPolicyLabel'
Catalog No. 61-531-0 Supplier Tocris Bioscience™ missing translation for 'supplierNo' 6153/10
Only null left
Add to cart
Add to cart
missing translation for 'nonReturnableMessage' missing translation for 'returnPolicyLabel'

Description

Potent and selective SAM-competitive EZH2 inhibitor

JQEZ5 is a potent and selective SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 11 nM). Selectively binds EZH2 over a panel of 22 methyltransferases. Reduces global level of the PRC2-associated mark H3K27me3 in K562 cells. Suppresses cell growth in CML cells. Inhibits colony formation of primary human CD34+ CML stem/ progenitor cells. Antitumor effects in vivo.

Specifications

Chemical Name or Material N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
CAS 1913252-04-6
Quantity 10 mg
Molecular Formula C30H38N8O2
Purity 98%
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.