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  5. Tocris™ JTP 103237

Tocris™ JTP 103237

Catalog No. 676550
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Catalog No. Quantity
67-655-0 50 mg
67-651-0 10 mg
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Catalog No. 67-655-0 Supplier Tocris™ Supplier No. 6765/50

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Description

Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor

JTP 103237 is a potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (IC50 = 20 - 40 nM). Displays >7000-fold selectivity for human MOGAT2 over human DGAT2. Modulates intestinal lipid absorption in mice. Decreases triglyceride, diacylglycerol and fatty acid synthesis in mouse model of fatty liver. Chronic treatment decreases hepatic triglyceride content and body weight, and improves glucose tolerance in diet-induced obese mice.

Specifications

Chemical Name or Material 7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine
CAS 1883864-16-1
Quantity 50 mg
Molecular Formula C24H29F3N6O
Purity 98%
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