JUN Mouse anti-Human, Mouse, Rat, Clone: 1G6B11, Proteintech

Catalog No.	Quantity
50-173-6745	150 μL

Catalog No. 50-173-6745 Supplier Proteintech Group Inc Supplier No. 663131IG150UL

Description

Mouse Monoclonal Antibody

This antibody is raised against a region of human JUN. Both phosphorylated (p-c-Jun) and unphosphorylated forms of c-Jun, with sizes of 42-45 kDa and 36-39 kDa, respectively are obtain in some experiments.

Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ′leucine-zipper′ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.

Specifications

• Antigen: JUN
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 1G6B11
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: JUN
• Gene Accession No.: P05412, P05627, P17325
• Gene Alias: Activator protein 1, AP 1, AP1, c Jun, JUN, jun oncogene, P39, Proto oncogene c Jun, Transcription factor AP 1
• Gene Symbols: Jun
• Host Species: Mouse
• Immunogen: JUN Fusion Protein Ag17639
• Purification Method: Protein G
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16476, 24516, 3725
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1