Tocris Bioscience JW 67
Wnt pathway inhibitor; induces degradation of active β-catenin
Manufacturer: Tocris Bioscience 4651/10
DescriptionInhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM).
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