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Tocris Bioscience™ JW 67

Catalog No. 465110
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465110 10 mg
46-515-0R 50 mg
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Catalog No. 465110 Supplier Tocris Bioscience™ Supplier No. 4651/10
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Description

Wnt pathway inhibitor; induces degradation of active β-catenin

JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM).

Specifications

Purity >97%
Quantity 10 mg
Product Type JW 67
Molecular Weight (g/mol) 394.38
Inhibitors JW 67

For Research Use Only

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