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Medchemexpress LLC Trispiro[3H-indole-3,2'-dioxane-2",3'''-[3H]indole]-2,2'''(1H,1'''H)-dione | 442644-28-2 | MFCD03036757 | 98.2% | 394.38 g·mol⁻¹ | C21H18N2O6 | 5 MG
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Supplier:  Medchemexpress LLC HY1084425MG

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JW67 (CAS 442644-28-2) is a small-molecule research inhibitor of canonical Wnt signaling that reduces active β-catenin by modulating the β-catenin/GSK-3β/AXIN/APC/CK1 multiprotein complex. It shows reported activity against colorectal cancer cell growth and is supplied for laboratory use as a light-yellow solid or as a 10 mM solution in DMSO.

  • Inhibits canonical Wnt signaling (IC50 1.17 μM).
  • Reduces active β-catenin via multiprotein complex modulation.
  • Reported activity against colorectal cancer cell growth.
  • Supplied in solid and solution formats for research use.
  • High purity (≈98.2%).
  • Molecular weight 394.38 g·mol⁻¹; formula C21H18N2O6.
  • Stable under recommended storage conditions for powder and solvent preparations.

Catalog No. 50-002-63686


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