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Invitrogen™ K-Ras Monoclonal Antibody (9.13)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ 415700

Description
This antibody is specific for human K-Ras (K-Ras2, Ki-Ras, c-K-ras, GTPase KRas) protein (accession # NP_004976.2, P01116), which is 100% homologous with mouse, 95% with rat, and 94% with bovine, respectively. Reactivity has been confirmed on western blots with human HeLa and WI-38 cell lysates as well as rat KNRK and mouse NIH 3T3 cell lysates, and identifies the target band at~21 kDa. The reactivity has been also confirmed with rat KNRK cells using immunoprecipitation and with HeLa cells by immunofluorescence. Based on amino acid sequence homology, reactivity with bovine is also expected.
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
Specifications
K-Ras | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.1% sodium azide; pH 7.4 | |
P01116, P08644, P32883 | |
KRAS | |
Immunogen corresponds to aa 170-180 from P01116-1 (isoform 2A) of human K-Ras. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 |
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
9.13 | |
Unconjugated | |
KRAS | |
AI929937; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; CFC2; c-Ki-ras; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-K-ras; c-K-ras2 protein; fa04e08; fc14b12; fc23g10; fj89d12; GTPase KRas; GTPase KRas, N-terminally processed; hypothetical protein LOC445289; K RAS; ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral (Kras-2) oncogene homolog; Kirsten rat sarcoma viral oncogene; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); KRAS; K-ras; K-Ras 2; K-ras p21 protein; KRAS proto-oncogene, GTPase; KRAS1; Kras2; Kras-2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; NS; NS3; oncogene KRAS2; p21; p21 protein; p21B; p21ras; PR310 c-K-ras oncogene; RALD; ras; ras p21; RASK; RASK2; ras-like protein; transforming protein p21; Unknown; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; xRAS2; zgc:85725 | |
Mouse | |
Protein A | |
RUO | |
16653, 24525, 3845 | |
-20°C | |
Liquid | |
Responsibly packaged |
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