Invitrogen™ K-Ras Monoclonal Antibody (F132-62)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA191046

Catalog No. PIMA191046

Description

Recommended positive controls: Sw480 or Y1 cells or normal skin tissue..

K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.

Specifications

• Antigen: K-Ras
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: 0.05M sodium phosphate with 0.2% gelatin and 0.1% sodium azide
• Gene Accession No.: P01116, P08644, P32883
• Gene Symbols: KRAS
• Immunogen: Recombinant full length human protein.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry
• Clone: F132-62
• Conjugate: Unconjugated
• Gene: KRAS
• Gene Alias: AI929937; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; CFC2; c-Ki-ras; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-K-ras; c-K-ras2 protein; fa04e08; fc14b12; fc23g10; fj89d12; GTPase KRas; GTPase KRas, N-terminally processed; hypothetical protein LOC445289; K RAS; ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral (Kras-2) oncogene homolog; Kirsten rat sarcoma viral oncogene; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); KRAS; K-ras; K-Ras 2; K-ras p21 protein; KRAS proto-oncogene, GTPase; KRAS1; Kras2; Kras-2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; NS; NS3; oncogene KRAS2; p21; p21 protein; p21B; p21ras; PR310 c-K-ras oncogene; RALD; ras; ras p21; RASK; RASK2; ras-like protein; transforming protein p21; Unknown; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; xRAS2; zgc:85725
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 16653, 24525, 3845
• Content And Storage: 4°C, do not freeze
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov