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  5. Tocris Bioscience™ Kainic acid

Tocris Bioscience™ Kainic acid

Catalog No. 02221
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Catalog No. Quantity
02-221 1 mg
02-221-0 10 mg
02-225-0 50 mg
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Catalog No. 02-221 Supplier Tocris Bioscience™ Supplier No. 0222/1
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Description

Kainate agonist; excitant and neurotoxin

Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC50 = 0.6 - 7.4 μM) and a partial agonist at AMPA receptors (EC50 = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimer's disease.

Related compounds include synthetic Kainic acid (Cat. No. 7065), the kainate receptor agonist Domoic acid (Cat. No. 0269) and the antagonist NBQX (Cat. No. 0373).

Specifications

Chemical Name or Material (2 S,3 S,4 S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
CAS 487-79-6
Assay Percent Range >98%
Quantity 1 mg
Solubility Soluble to 25mM in water with gentle warming
Target Kainate Receptor Agonists
Molecular Formula C10H15NO4
Formula Weight Observed MW: 213.23
Purity 98%

For Research Use Only

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