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MilliporeSigma™ KAT7 (HBO1 / MYST2), Rabbit, Unlabeled, Polyclonal,

Catalog No. ABE1436 Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABE1436 100 μg Unconjugated
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Catalog No. ABE1436 Supplier MilliporeSigma™ Supplier No. ABE1436
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Description

Rabbit Polyclonal Antibody

Histone acetyltransferase KAT7 (EC 2.3.1.48; UniProt Q5SVQ0; also known as Histone acetyltransferase binding to ORC1, Lysine acetyltransferase 7, MOZ, MYST-2, SAS2 and TIP60 protein 2, YBF2/SAS3) is encoded by the Kat7 (also known as Hbo1, Myst2) gene (Gene ID 217127) in murine species. KAT7 is a MYST ( MOZ, Ybf2/Sas3, Sas2, and Tip60) family histone acetyltransferase (HAT) originally characterized as a HAT bound to origin recognition complex 1 (ORC1) and named HBO1. KAT7 displays histone H4-specific acetyltransferase activity with reduced activity toward histone H3. KAT7 plays an essential role in adipogenesis, embryonic development, and the survival of erythroblasts in fetal liver. KAT7 interacts with two JADE1 isoforms, JADE1S and JADE1L, that promote KAT7-mediated acetylation of nucleosomal histones. The KAT7-JADE1 complex shows cell cycle-dependent chromatin shuttling during mitosis via a mechanism linked to JADE1 phosphorylation. Nuclear JADE1S and HBO1 localization correlates with that of cell proliferation marker Ki67 and bulk histone H4 acetylation. KAT7 upregulation has been reported in some human cancers and tumor suppressor p53 expression suppresses KAT7 HAT activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KAT7 (HBO1 / MYST2)
Applications Western Blot
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Kat7, Hbo1, Myst2
Gene Accession No. Q5SVQ0
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding to a central region sequence within the N-terminal half of human/mouse/rat KAT7 (HBO1/MYST2).
Purification Method Affinity Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_001181932
Test Specificity This rabbit polyclonal antibody targets a central region sequence present in all human, murine, and rat KAT7 (HBO1/MYST2) spliced isoforms reported by UniProt (O95251, Q5SVQ0, Q810T5).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
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For Research Use Only. Not for use in diagnostic procedures.

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