KCNK18 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-4109	Proteintech Group Inc 237121AP150UL	150 μL

Description

This antibody can be used to detect endogenous KCNK18, however, the reason for the additional band of 130-140 kDa is still unknown.

TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.

Specifications

• Antigen: KCNK18
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q7Z418
• Gene ID (Entrez): 338567
• Immunogen: KCNK18 Fusion Protein Ag20514
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: KCNK18

• Concentration: 0.45 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: K2p18.1, KCNK18, TRESK, TRESK 2, TRESK2, TRIK
• Gene Symbols: KCNK18
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody