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Invitrogen™ KCNK2 Polyclonal Antibody
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Catalog No. 01670158
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100 μL
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Catalog No. Quantity
01-670-158 100 μL
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Catalog No. 01-670-158 Supplier Invitrogen™ Supplier No. PA116981
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Description

Rabbit Polyclonal Antibody

This antibody is 88% homologous to rat. It is not recommended for ICC/IF or Immunohistochemistry applications.

TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KCNK2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene KCNK2
Gene Accession No. O95069, P97438
Gene Alias A430027H14Rik; AI848635; arachidonic acid sensitive tandem pore domain potassium channel; EMBL:AAU06141.1, ECO:0000312; Ensembl:ENSRNOP00000003684, ECO:0000312; hTREK-1c; hTREK-1e; ion transport membrane protein; K2p2.1; K2P2.1 potassium channel; KCNK2; kcnk2 {ECO:0000312; Kcnk2 potassium channel; outward rectifying potassium channel protein TREK-1; outward rectifying potassium channel protein TREK-1 {ECO:0000250; Potassium channel subfamily K member 2; potassium channel subfamily K member 2 {ECO:0000250; potassium channel subfamily k member 2 variant 1; potassium channel subfamily k member 2 variant 2; potassium channel, subfamily K, member 2; potassium channel, two pore domain subfamily K, member 2; potassium inwardly-rectifying channel, subfamily K, member 2; potassium two pore domain channel subfamily K member 2; PubMed:16248991}; PubMed:24196565}; RGD:621448}; rTREK1d; Stretch-activated potassium channel TREK-1; stretch-activated potassium channel TREK-1 {ECO:0000303; tandem-pore-domain potassium channel TREK-1; TPKC1; TREK; trek 1; TREK1; TREK-1; TREK-1 K(+) channel subunit; TREK-1 K(+) channel subunit {ECO:0000250; TWIK-related potassium channel 1; two pore domain potassium channel TREK-1; two pore domain potassium channel TREK-1 {ECO:0000303; Two pore potassium channel TPKC1; two pore potassium channel TPKC1 {ECO:0000250; two-pore potassium channel 1; UniProtKB:O95069}
Gene Symbols KCNK2
Host Species Rabbit
Immunogen A synthetic peptide made to an N-terminal region of human TREK 1 (within residues 1-100).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16526, 282590, 3776
Target Species Human, Mouse, Bovine
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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