Invitrogen™ KCNQ2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1929

Catalog No. PA1929

Description

PA1-929 detects KCNQ2 from mouse, human and rat samples. This antibody is specific for KCNQ2 and does not detect KCNQ1, KCNQ3, KCNQ4 or KCNQ5. PA1-929 has been successfully used in Western blot, immunofluorescence, immunohistochemistry and immunocytochemistry procedures. Immunohistochemical staining of rat hippocampal using PA1-929 yielded a strong signal in granule cell layer and the mossy fibers found in the central hilus of the dentate gyrus. PA1-929 immunogen is a GST fusion protein encoding the first 70 amino acids of human KCNQ2.

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.

Specifications

• Antigen: KCNQ2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNQ2
• Gene Alias: BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KCNQ2; KQT like 2; KQT2; KQT-like 2; KV7.2; KVEBN1; mKQT2.3; mKQT2.4; neuroblastoma-specific potassium channel subunit alpha KvLQT2; Nmf134; potassium channel subunit alpha KvLQT2; potassium channel, voltage gated KQT-like subfamily Q, member 2; potassium channel, voltage-gated KQT-like subfamily Q, member 2; potassium voltage-gated channel KQT-like subfamily member 2.3; potassium voltage-gated channel KQT-like subfamily member 2.4; potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel subfamily Q member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; potassium voltage-gated channel, subfamily Q, member 2; voltage-gated potassium channel subunit Kv7.2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16536, 170848, 3785
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.02% sodium azide
• Gene Accession No.: O43526, O88943, Q9Z351
• Gene Symbols: KCNQ2
• Immunogen: GST fusion protein encoding the first 70 amino acids of human KCNQ2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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