Invitrogen™ KCNQ4 Monoclonal Antibody (N43/6), PerCP

Catalog No.	Quantity
PIMA545413	100 μg

Catalog No. PIMA545413

Supplier: Invitrogen™ MA545413

Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45413 was sufficient for detection of KCNQ4 in 10 μg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 77kDa.

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2, an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: KCNQ4
• Applications: Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot, Immunocytochemistry, Microarray
• Classification: Monoclonal
• Clone: N43/6
• Concentration: 1 mg/mL
• Conjugate: PerCP
• Formulation: 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
• Gene: KCNQ4
• Gene Accession No.: P56696, Q9JK96, Q9JK97
• Gene Alias: DFNA 2; DFNA2; DFNA2A; KCNQ 4; KCNQ4; KQT like 4; KQT-like 4; KV7.4; LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 4; potassium channel KQT-like 4; potassium channel subunit alpha KvLQT4; potassium channel, voltage gated KQT-like subfamily Q, member 4; potassium channel, voltage-gated KQT-like subfamily Q, member 4; potassium voltage-gated channel KQT-like protein 4; potassium voltage-gated channel KQT-like subfamily member 4; potassium voltage-gated channel subfamily KQT member 4; potassium voltage-gated channel subfamily Q member 4; potassium voltage-gated channel, KQT-like subfamily, member 4; potassium voltage-gated channel, subfamily Q, member 4; voltage-gated potassium channel subunit Kv7.4
• Gene Symbols: KCNQ4
• Host Species: Mouse
• Immunogen: Fusion protein amino acids 2-77 of human KCNQ4.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 298496, 60613, 9132
• Target Species: Human, Mouse, Rat
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1