Invitrogen™ KDEL Receptor Pan Monoclonal Antibody (KR-10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA190944

Catalog No. PIMA190944

Description

Store as a concentrated solution. Centrifuge briefly prior to opening vial.

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.

Specifications

• Antigen: KDEL Receptor Pan
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: O43731, P24390, P33946, P33947, Q2KJ37, Q569A6, Q5U305, Q7ZXS5, Q8R1L4, Q99JH8, Q9CQM2
• Gene Symbols: KDELR1, KDELR2, kdelr2.L, KDELR3
• Immunogen: Synthetic peptide conjugated to KLH, corresponding to amino acids 192-212 of Cow KDEL Receptor.
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Rabbit, Monkey, Bovine, Hamster, Pig, Frog
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: KR-10
• Conjugate: Unconjugated
• Gene: KDELR3
• Gene Alias: (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; 1110007A14Rik; 8030486F04Rik; AI173274; AW215843; BEST:CK00230; CG5183; CG5183-PA; CG5183-PB; CG5183-PC; CK00230; Dmel\CG5183; Dmel_CG5183; dmErd2; ELP-1; ER lumem protein retaining receptor 2; ER lumen protein retaining receptor; ER lumen protein retaining receptor 1; ER lumen protein retaining receptor 2; ER lumen protein retaining receptor 3; ER lumen protein-retaining receptor; ER lumen protein-retaining receptor 1; ER lumen protein-retaining receptor 2; ER lumen protein-retaining receptor 3; ERD2; Erd2.1; ERD2.2; ERD23; ERD2L3; ERD-2-like protein; ERD2-like protein 1; ergr15; HDEL; hypothetical protein; I79_001653; I79_020931; I79_023963; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; KDEL endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2 L homeolog; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor; KDEL receptor 1; KDEL receptor 2; KDEL receptor 3; KDEL receptor-like protein; KDELR; Kdelr1; Kdelr2; kdelr2.L; KDELR3; KDEL-receptor; KdelR-PA; KdelR-PB; KdelR-PC; l(2)31Em; l(2)k00311; lethal (2) 31Em; PM23; Putative MAPK-activating protein PM23; RCJMB04_8l23; Unknown (protein for MGC:128955); XELAEV_18045328mg
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100338388, 100338871, 100349892, 100514523, 100520962, 100625446, 100750636, 100750912, 100765889, 105785, 10945, 11014, 11015, 304290, 315131, 361577, 380330, 474509, 484406, 509687, 531676, 612839, 618184, 66913, 68137
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid