KDM3A Monoclonal Antibody (OTI5A7), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-4428	100 μL

Catalog No. 50-168-4428 Supplier OriGene Supplier No. TA812138

Description

Mouse Monoclonal Antibody

JMJD1A is a histone demethylase that specifically demethylates ′Lys-9′ of histone H3, thereby playing a central role in histone code. It preferentially demethylates mono- and dimethylated H3 ′Lys-9′ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ′Lys-9′. Demethylation of Lys residue generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ′Lys-9′ demethylation and transcriptional activation. It′s also Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Specifications

• Antigen: KDM3A
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI5A7
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: KDM3A
• Gene Accession No.: Q9Y4C1
• Gene Alias: JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA
• Gene Symbols: KDM3A
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 850-1321 of human KDM3A produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55818
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1