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Invitrogen™ Kinesin 5B Monoclonal Antibody (KN-02)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA119352
Description
This antibody recognizes heavy chain of conventional kinesin, a protein associated with intracellular vesicles, and with lower affinity with denaturated molecule. Epitope is located in coiled-coil stalk domain. It stains Western blots of kinesin-enriched preparations. Epitope mapping (by limited proteolysis of partially purified porcine kinesin) followed by immunoblotting has revealed that antibodies KN-01, KN-02 and KN-03 react with different sets of fragments. The antibody KN-02 does not react with kinesin bound to taxol-stabilized microtubules.
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
Specifications
Kinesin 5B | |
Monoclonal | |
1 mg/mL | |
TBS with 15mM sodium azide; pH 8 | |
P33176, Q2PQA9, Q61768 | |
KIF5B | |
Enriched fraction of porcine brain kinesin. | |
100 μg | |
Primary | |
Human, Mouse, Rat, Pig | |
Antibody | |
IgM |
Immunohistochemistry (Paraffin), Immunocytochemistry | |
KN-02 | |
Unconjugated | |
KIF5B | |
AL022807; Conventional kinesin heavy chain; EMBL:ABC25059.1}; epididymis secretory protein Li 61; HEL-S-61; Khc; Khcs; KIF5A; KIF5B; kif5b {ECO:0000312; kinesin 1 (110-120kD); kinesin family member 5A; kinesin family member 5B; kinesin heavy chain; kinesin heavy chain member 5B, ubiquitous; kinesin-1 heavy chain; KINH; KNS; Kns1; ubiquitous kinesin heavy chain; UKHC; U-KHC; Unknown (protein for IMAGE:7944745) | |
Mouse | |
Sequential Chromatography | |
RUO | |
117550, 16573, 3799, 595132 | |
4°C, do not freeze | |
Liquid |
Safety and Handling
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